(Ich füttere 10g Lysin am Tag. Fällt mir nur gerade auf, weil ich den Lysingehalt gesehen habe. Hat nix mit den B Vitaminen zu tun.
)Hier ist noch mehr über B Vitamine (das ist ein Beitrag aus den Files der EC/IR Gruppe, ursprünglich mal eine Antwort auf eine Frage eines Mitglieds). Und da geht es um hohe Dosen, also nicht recht geringe.
"Might as well mention B vitamins here since you've asked about them before. The B group of vitamins is absolutely essential to the normal metabolism of fats, proteins and carbohydrates. Higher reliance on protein as an energy source in long standing diabetes or
insulin resistance might even increase the requirement for Bs critical to protein metabolism (like B-6, B-12, biotin,folate). However, megadosing is not going to help and high doses of some Bs, like niacin and pyridoxine can be detrimental to an insulin resistant animal by blocking fatty acid utilization and causing accelerated loss of glycogen.
Some vitamin deficiencies (D, pyridoxine, riboflavin) have been linked to glucose intolerance but in every case the mechanism has been by decreased insulin secretion, rather than insensitivity to insulin - i.e. low insulins. In the case of pyridoxine (B6) at least (and I think vitamin D too), deficiency actually results in a degree of INCREASED insulin sensitivity. The one instance where correction of B6 deficiency has resulted in improved insulin sensitivity is in women taking birth control pills. In this case though, the mechanism
of the insulin resistance is theorized (not proven) to be mediated through changes in metabolism of the amino acid tryptophan, with indirect effects on insulin action.
Related issues concerning B6 (and I think where your interest lies) are interest in its potential to increase levels of serotonin and GABA in the brain (calming/antianxiety chemicals) and to decrease the sensitivity of cellular receptors to corticosteroids (an antistress effect). However, these potential effects are not well studied and need to weighed against negative effects of high dose pyridoxine on glycogen status, which is already impaired in insulin resistance.
Bottom line for me from the solid information available to date is that when you are talking specifically about insulin resistance (high insulin, high to normal glucose) there is no convincing evidence of any therapeutic benefit to be gained from high dose B supplementation, or involvement of B deficiencies in the pathogenesis. Pyridoxine may eventually prove to be an exception here in high cortisol states but even then the indication would be for correction of a deficiency, not megadosing. If B6 helps your horse, by all means use it but for now it looks like it would be best to keep intake of this and all B vitamins in a physiologic range."
Ich habe ja nur einen IRler, und Heu gibt es hier ad lib, also gebe ich nur Biotin zu.
Also unbedenklich?
